ВРОДЖЕНІ ВАДИ РОЗВИТКУ, ПОЛІССЯ, ЧОРНОБИЛЬ

W Wertelecki, B. Ievtushok, N. Zymak-Zakutnia, S. Kalynka, Y. Korzhynskyy, S. Lapchenko, Z. Sosyniuk

Анотація


Населення рівненського Полісся - популяція, що найбільше зазнала хронічного опромінення іонізуючою радіацією внаслідок Чорнобильської катастрофи. Метою нашого дослідження було визначити популяційні частоти вроджених вад розвитку (ВВР) у Рівненській області за 2000- 2014 рр. та їх контрасти у поліському та не-Поліському регіонах області, провести аналіз ймовірних етіологічних факторів. 


Ключові слова


Вроджені вади розвитку; вади невральної трубки; мікроцефалія; мікрофтальмія; тератоген; радіація; Чорнобиль; Полісся.

Повний текст:

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Посилання


Likhtarev IA, Kovgan LN, Vavilov SE, et al. Internal exposures from the ingestion of foods contaminated by 137Cs after theChernobylaccident--report 2. Ingestion doses of the rural population ofUkraineup to 12 y after the accident (1986-1997). Health Phys 2000;79(4):341-57.

Dancause K, Yevtushok L, Lapchenko S, Shevchenko G, Wertelecki W, Garruto R. Chronic Radiation Exposure in the Rivne-Polissia Region of Ukraine: Implications for Births Defects. Am J Hum Biol 2010;22:657-74.

Yuskiv N, Andelin C, Polishuk S, Shevchuk O, Sosynyuk Z, Vihovska T, Yevtushok L, Oakley J Jr, Wertelecki W. High rates of neural tube defects inUkraine. Birth Defects Res A Clin Mol Teratol 2004;70:400-02.

Wertelecki W.Malformations in a Chornobyl-impacted region. Pediatrics 2010;125:836-43.

Wertelecki W, Yevtushok L, Zymak-Zakutnia N, et al. Blastopathies and microcephaly in a Chornobyl impacted region ofUkraine. Congenit Anom (Kyoto) 2014;54(3):125-49.

Wertelecki W. Birth defects surveillance inUkraine: a process. J Appl Genet 2006; 47(2):143-49.

Yevtushok L, Zymak-Zakutnia N, Kalynka S, Korzhynsky Y. Sosyniuk Z, Wertelecki W. Birth Defects Population Monitoring Based on International Standards. Archives of Clinical and Experimental Medicine 2012;21(2):153-56 [In Ukrainian].

Bakhireva LN; Wilsnack SC; Kristjanson A, Yevtushok L, Onishenko S, Wertelecki W, Chambers CD. Paternal drinking, intimate relationship quality, and alcohol consumption in pregnant Ukrainian women. Journal of Studies on Alcohol and Drugs. 2011;72(4):536-44.

EUROCAT Guide 1.4 and reference documents 2013. Available at: http://www.eurocat-network.eu/aboutus/datacollection/guidelinesforregistration/guide1_4 [Accessed 17 Mar 2016].

WHO Child Growth Standards: Head Circumference-for-age. Available at: http://www.who.int/childgrowth/standards/hc_for_age/en/ [Accessed 15 Apr 2015].

European Surveillance of Congenital Anomalies (EUROCAT). Available at:

http://www.eurocat-network.eu/accessprevalencedata/prevalencetables)

[Accessed 29 Jan 2015].

Wertelecki W, Koerblein A, Ievtushok B, Zymak-Zakutnia N, et al. Elevated Congenital Anomaly Rates and Incorporated Cesium-137 inthe Polissia Region of Ukraine. Birth Defects Res A Clin Mol Teratol 2016 Feb 12. doi: 10.1002/bdra.23476.

Dolk H, Nichols R, EUROCAT Working Group. Evaluation of the impact ofChernobylon the prevalence of congenital anomalies in 16 regions ofEurope. Int J Epidemiol 1999;28:941-48.

Hoffman M, Fleming M. Chernobyl: The True Scale of the Accident 20 Years Later a UN Report Provides Definitive Answers and Ways to Repair Lives, IAEA, WHO, UNDP. IAEA, WHO, UNDP, Press Release; September 5, 2005.

Parker L, Pearce MS, Dickinson HO, Aitkin M, Craft AW. Stillbirths among offspring of male radiation workers at Sellafield nuclear reprocessing plant. Lancet 1999;354:1407-14.

Sever LE, Hessol NA, Gilbert ES, McIntyre JM. The prevalence at birth of congenital malformations in communities near theHanfordsite. American Journal of Epidemiology 1988;127(2):243-54.

Centers for Disease Control and Prevention. Notes from the Field: Investigation of a Cluster of Neural Tube Defects —Central Washington, 2010–2013. MMWR 2013; 62:728.

Courtemanche C, Huang AC, Elson-Schwab I, Kerry N, Ng BY, Ames BN. Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison. FASEB J 2006;18(1):209-11.

Oakley GP. The scientific basis for eliminating folic acid-preventable spina bifida: a modern miracle from epidemiology. Ann Epidemiol 2009;19:226-30.

Pauniaho SL, Heikinheimo O, Vettenranta K, Salonen J, Stefanovic V, Ritvanen A, Rintala R, Heikinheimo M. High prevalence of sacrococcygeal teratoma in Finland - a nationwide population-based study. Acta Paediatr 2013 Jun;102(6):e251-6. doi: 10.1111/apa.12211.

Juriloff D, Harris J. Hypothesis: The female excess in cranial neural tube defects reflects and epigenetic drag of the inactivating X chromosome on the molecular mechanisms of neural fold elevation. Birth Defects Research Part A. 2012;94:849-55.


Пристатейна бібліографія ГОСТ


1. Internal exposures from the ingestion of foods contaminated by 137Cs after theChernobylaccident--report 2. Ingestion doses of the rural population ofUkraineup to 12 y after the accident (1986-1997) / IA. Likhtarev, LN. Kovgan, SE. Vavilov [et al.] // Health Phys.− 2000.−Vol.79(4).−P.341-357.

 

2. Chronic Radiation Exposure in the Rivne-Polissia Region ofUkraine: Implications for Births Defects / K. Dancause, L. Yevtushok, S. Lapchenko [et al.] // Am J Hum Biol.− 2010.− Vol.22.−P.657-674.

 

3. High rates of neural tube defects in Ukraine / N. Yuskiv, C. Andelin, S. Polishuk [et al.] // Birth Defects Res A Clin Mol Teratol.− 2004.− Vol.70.−P.400-402.

 

4. Wertelecki W. Malformations in a Chornobyl-impacted region / W.Wertelecki // Pediatrics.− 2010.− Vol.125.−P.836-843.

 

5. Blastopathies and microcephaly in a Chornobyl impacted region of Ukraine / W. Wertelecki, L. Yevtushok, N. Zymak-Zakutnia [et al.] // Congenit Anom (Kyoto).− 2014.− Vol.54(3).−P.125-49.

 

6. Wertelecki W. Birth defects surveillance inUkraine: a process / W.Wertelecki // J Appl Genet.− 2006.− Vol.47(2).−P.143-149.

 

7. Birth Defects Population Monitoring Based on International Standards / L. Yevtushok, N. Zymak-Zakutnia, S. Kalynka [et al.] // Archives of Clinical and Experimental Medicine.− 2012.− Vol.21(2).−P.153-156 [In Ukrainian].

 

8. Paternal drinking, intimate relationship quality, and alcohol consumption in pregnant Ukrainian women / LN Bakhireva, SC Wilsnack, A Kristjanson [et al.] // Journal of Studies on Alcohol and Drugs.− 2011.− Vol.72(4).−P.536-544.

 

9. EUROCAT Guide 1.4 and reference documents 2013 [Електронний ресурс]. – Режим доступу: http://www.eurocat-network.eu/aboutus/datacollection/guidelinesforregistration/guide1_4

 

10. WHO Child Growth Standards: Head Circumference-for-age. [Електронний ресурс]. – Режим доступу: http://www.who.int/childgrowth/standards/hc_for_age/en/

 

11. European Surveillance of Congenital Anomalies (EUROCAT). [Електронний ресурс]. – Режим доступу: http://www.eurocat-network.eu/accessprevalencedata/prevalencetables)

 

12., Zymak-Zakutnia N, et al. Elevated Congenital Anomaly Rates and Incorporated Cesium-137 inthe Polissia Region of Ukraine / W. Wertelecki, A. Koerblein, B. Ievtushok [et al.] // Birth Defects Res A Clin Mol Teratol.− 2016. doi: 10.1002/bdra.23476.

 

13. Dolk H. EUROCAT Working Group. Evaluation of the impact ofChernobylon the prevalence of congenital anomalies in 16 regions ofEurope/ H. Dolk, R. Nichols // Int J Epidemiol.− 1999.− Vol.28.−P.941-948.

 

14. Hoffman M. Chernobyl: The True Scale of the Accident 20 Years Later a UN Report Provides Definitive Answers and Ways to Repair Lives / M. Hoffman, M. Fleming // IAEA, WHO, UNDP. IAEA, WHO, UNDP, Press Release.− 2005.

 

15. Stillbirths among offspring of male radiation workers at Sellafield nuclear reprocessing plant / L. Parker, MS. Pearce, HO. Dickinson [et al.] // Lancet.− 1999.− Vol.354.−P.1407-1414.

 

16. The prevalence at birth of congenital malformations in communities near theHanfordsite / LE. Sever, NA. Hessol, ES. Gilbert [et al.] // American Journal of Epidemiology.− 1988.− Vol.127(2).−P.243-254.

 

17. Centers for Disease Control and Prevention. Notes from the Field: Investigation of a Cluster of Neural Tube Defects —Central Washington, 2010–2013 // MMWR.−2013.− Vol.62.−P.728.

 

18. Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison / C. Courtemanche, AC. Huang, I. Elson-Schwab [et al.] // FASEB.− 2006.− Vol.18(1).−P.209-211.

 

19. Oakley GP. The scientific basis for eliminating folic acid-preventable spina bifida: a modern miracle from epidemiology / GP. Oakley // Ann Epidemiol.− 2009.− Vol.19.−P.226-230.

 

20. High prevalence of sacrococcygeal teratoma in Finland - a nationwide population-based study / SL. Pauniaho, O. Heikinheimo, K. Vettenranta  [et al.] //Acta Paediatr.− 2013.− Vol.102(6).−P.e251-6. doi: 10.1111/apa.12211.

 

21. Juriloff D. Hypothesis: The female excess in cranial neural tube defects reflects and epigenetic drag of the inactivating X chromosome on the molecular mechanisms of neural fold elevation / D. Juriloff, J. Harris // Birth Defects Research Part A.− 2012.− Vol.94.−P.849-855.





DOI: https://doi.org/10.24061/2226-1230.2(20).2016.78277.%p

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Журнал «Неонатологія, хірургія та перинатальна медицина» ISSN 2413-4260 (Online), ISSN 2226-1230 (Print) This work is licensed under a Creative Commons Attribution 4.0 International License.