PЕТИНОПАТІЯ ПЕРЕДЧАСНО НАРОДЖЕНИХ. ПАТОГЕНЕЗ. МЕХАНІЗМИ РОЗВИТКУ. ЧАСТИНА 1. ФАКТОРИ РИЗИКУ.

Ya. I. Penishkevich, Y. D. Hodovanets, I. V. Koshurba

Анотація


Резюме. Незрілі сітківки передчасно народжених особливо сприйнятливі до пошкоджень, які переривають нейро-судинне розвиток, приводячи до ретинопатії недоношених. Придушення чинників зростання через гіпероксії і втрата материнської-ембріонального взаємодії призводять до затримки васкуляризації сітківки (фаза 1). Згодом, все більш метаболічно активна, але ще погано васкуляризованная сітківка стає гіпоксичної, стимулюючи викликану фактором зростання вазопрліферацію (фаза 2), яка може попрівесті до відшарування сітківки. У дуже передчасно народжених немовлят, контрольована подача кисню, зменшує, але не усуває ретинопатію недоношених дітей. Ідентифікація та контроль факторів, що сприяють розвитку ретинопатії недоношених, є основоположними для запобігання прогресування в важке, загрозливе зору захворювання і обмеження супутньої патології, з якою захворювання розділяє модифіковані фактори ризику. Стратегії в запобігання ретинопатії недоношених будуть залежати від оптимізації кисневої насиченості, харчування, і нормалізації концентрації основних чинників, таких як інсуліноподібний фактор росту 1 і ω-3 поліненасичені жирні кислоти, так само як обмеження ефектів інфекції і запалення, щоб викликати нормальний ріст і обмежити придушення нервово-судинного розвитку.

Ключові слова


око; ретинопатія передчасно народжених; патогенез; фактори ризику

Повний текст:

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Посилання


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Пристатейна бібліографія ГОСТ


1. Silverman WA. Retrolental fibroplasia: a modern parable. New York: Grune & Stratton; 1980.

2. Campbell K. Intensive oxygen therapy as a possible cause of retrolental fi broplasias: a clinical approach. Med J Aust. 1951 Jul 14;2(2):48-50.

3. Carlo WA, Finer NN, Walsh MC, Rich W, Gantz MG, Laptook AR, et al. Target ranges of oxygen saturation in extremely preterm infants. N Engl J Med. 2010 May 27;362(21):1959-69. doi: 10.1056/NEJMoa0911781.

4. Stenson B, Brocklehurst P, Tarnow-Mordi W. Increased 36-week survival with high oxygen saturation target in extremely preterm infants. N Engl J Med. 2011 Apr 28;364(17):1680-2. doi: 10.1056/NEJMc1101319.

5. Chen J, Smith LE. Retinopathy of prematurity. Angiogenesis. 2007;10(2):133-40. doi: 10.1007/s10456-007-9066-0.

6. Heidary G, Vanderveen D, Smith LE. Retinopathy of prematurity: current concepts in molecular pathogenesis. Semin Ophthalmol. 2009 Mar-Apr;24(2):77-81. doi: 10.1080/08820530902800314.

7. Rivera JC, Sapieha P, Joyal JS, Duhamel F, Shao Z, Sitaras N, et al. Understanding retinopathy of prematurity: update on pathogenesis. Neonatology. 2011;100(4):343-53. doi: 10.1159/000330174.

8. Raghuveer TS, Bloom BT. A paradigm shift in the prevention of retinopathy of prematurity. Neonatology. 2011;100(2):116-29. doi: 10.1159/000322848.

9. Mataftsi A, Dimitrakos SA, Adams GG. Mediators involved in retinopathy of prematurity and emerging therapeutic targets. Early Hum Dev. 2011 Oct;87(10):683-90. doi: 10.1016/j.earlhumdev.2011.05.009.

10. Lee J, Dammann O. Perinatal infection, inflammation, and retinopathy of prematurity. Semin Fetal Neonatal Med. 2012 Feb;17(1):26-9. doi: 10.1016/j.siny.2011.08.007.

11. Hartnett ME, Penn JS. Mechanisms and management of retinopathy of prematurity. N Engl J Med. 2012 Dec 27;367(26):2515-26. doi: 10.1056/NEJMra1208129.

12. Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008 Jan 5;371(9606):75-84. doi: 10.1016/S0140-6736(08)60074-4.

13. Lawn JE, Gravett MG, Nunes TM, Rubens CE, Stanton C. Global report on preterm birth and stillbirth (1 of 7): defi nitions, description of the burden and opportunities to improve data. BMC Pregnancy Childbirth. 2010 Feb 23;10(Suppl 1):1. doi: 10.1186/1471-2393-10-S1-S1.

14. Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012 May 11;379(9832):2151–61. doi: http://dx.doi.org/10.1016/S0140-6736(12)60560-1.

15. Austeng D, Källen KB, Ewald UW, Jakobsson PG, Holmström GE. Incidence of retinopathy of prematurity in infants born before 27 weeks gestation in Sweden. Arch Ophthalmol. 2009 Oct;127(10):1315-9. doi: 10.1001/archophthalmol.2009.244.

16. Markestad T, Kaaresen PI, Rønnestad A, Reigstad H, Lossius K, Medbø S, et al. Early death, morbidity, and need of treatment among extremely premature infants. Pediatrics. 2005 May;115(5):1289-98.

17. Allegaert K, de Coen K, Devlieger H. Threshold retinopathy at threshold of viability: the EpiBel study. Br J Ophthalmol. 2004 Feb;88(2):239-42.

18. Darlow BA, Hutchinson JL, Henderson-Smart DJ, Donoghue DA, Simpson JM, Evans NJ. Prenatal risk factors for severe retinopathy of prematurity among very preterm infants of the Australian and New Zealand Neonatal Network. Pediatrics. 2005 Apr;115(4):990-6.

19. Weber C, Weninger M, Klebermass K, Reiter G, Wiesinger-Eidenberger G, Brandauer M, et al. Mortality and morbidity in extremely preterm infants (22 to 26 weeks of gestation): Austria 1999–2001. Wien Klin Wochenschr. 2005 Nov;117(21-22):740-6.

20. Tommiska V, Heinonen K, Lehtonen L, Renlund M, Saarela T, Tammela O, et al. No improvement in outcome of nationwide extremely low birth weight infant populations between 1996–1997 and 1999–2000. Pediatrics. 2007 Jan;119(1):29-36.

21. Fledelius HC, Dahl H. Retinopathy of prematurity, a decrease in frequency and severity. Trends over 16 years in a Danish county. Acta Ophthalmol Scand. 2000 Jun;78(3):359-61.

22. Lundqvist P, Källen K, Hallström I, Westas LH. Trends in outcomes for very preterm infants in the southern region of Sweden over a 10-year period. Acta Paediatr. 2009 Apr;98(4):648-53. doi: 10.1111/j.1651-2227.2008.01155.x.

23. Haines L, Fielder AR, Scrivener R, Wilkinson AR. Retinopathy of prematurity in the UK I: the organisation of services for screening and treatment. Eye (Lond). 2002 Jan;16(1):33-8.

24. Haines L, Fielder AR, Baker H, Wilkinson AR. UK population based study of severe retinopathy of prematurity: screening, treatment, and outcome. Arch Dis Child Fetal Neonatal Ed. 2005 May;90(3):240-4.

25. Holmström GE, Hellström A, Jakobsson PG, Lundgren P, Tornqvist K, Wallin A. Swedish national register for retinopathy of prematurity (SWEDROP) and the evaluation of screening in Sweden. Arch Ophthalmol. 2012 Nov;130(11):1418-24. doi: 10.1001/archophthalmol.2012.2357.

26. Tan SZ, Dhaliwal C, Becher JC, Fleck B. Trends in the incidence of retinopathy of prematurity in Lothian, south-east Scotland, from 1990 to 2009. Arch Dis Child Fetal Neonatal Ed. 2012 Jul;97(4):310-1. doi: 10.1136/fetalneonatal-2011-301464.

27. Hameed B, Shyamanur K, Kotecha S, Manktelow BN, Woodruff G, Draper ES, et al. Trends in the incidence of severe retinopathy of prematurity in a geographically defined population over a 10-year period. Pediatrics. 2004 Jun;113(6):1653-7.

28. Lad EM, Nguyen TC, Morton JM, Moshfeghi DM. Retinopathy of prematurity in the United States. Br J Ophthalmol. 2008 Mar;92(3):320-5. doi: 10.1136/bjo.2007.126201.

29. Lad EM, Hernandez-Boussard T, Morton JM, Moshfeghi DM. Incidence of retinopathy of prematurity in the United States: 1997 through 2005. Am J Ophthalmol. 2009 Sep;148(3):451-8. doi: 10.1016/j.ajo.2009.04.018.

30. Gunn DJ, Cartwright DW, Gole GA. Incidence of retinopathy of prematurity in extremely premature infants over an 18-year period. Clin Experiment Ophthalmol. 2012 Jan-Feb;40(1):93-9. doi: 10.1111/j.1442-9071.2011.02724.x.

31. Zin AA, Moreira ME, Bunce C, Darlow BA, Gilbert CE. Retinopathy of prematurity in 7 neonatal units in Rio de Janeiro: screening criteria and workload implications. Pediatrics. 2010 ; 126: e410–17.

32. Darlow BA, Zin AA, Beecroft G, Moreira ME, Gilbert CE. Capacity building of nurses providing neonatal care in Rio de Janeiro, Brazil: methods for the POINTS of care project to enhance nursing education and reduce adverse neonatal outcomes. BMC Nurs. 2012 Mar 12;11:3. doi: 10.1186/1472-6955-11-3.

33. Smith LE. Through the eyes of a child: understanding retinopathy through ROP the Friedenwald lecture. Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5177-82. doi: 10.1167/iovs.08-2584.

34. Patz A, Hoeck LE, De la Cruz E. Studies on the effect of high oxygen administration in retrolental fibroplasia: I. Nursery observations. Am J Ophthalmol. 1952 Sept;35(9):1248–53.

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DOI: https://doi.org/10.24061/2413-4260.VII.3.25.2017.12

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