DOI: https://doi.org/10.24061/2413-4260.IV.3.13.2014.18

РАННІЙ НЕОНАТАЛЬНИЙ СЕПСИС. ОСНОВНІ НАПРЯМКИ ДІАГНОСТИКИ ТА ЛІКУВАННЯ

E.A. Kostiyk, E.E. Shynko, Y.Y. Krasnova

Анотація


Неонатальний сепсис залишається провідною причиною захворюваності та смертності новонароджених. Ідентифікація новонароджених групи ризику з розвитку раннього неонатального сепсису має ґрунтуватися на сукупності материнських факторів ризику, даних клінічного огляду та лабораторних обстежень. Оптимальним лікуванням новонародженим з сепсисом чи підозрою на нього є застосування антибіотиків широкого спектру дії.

Ключові слова


новонароджені; сепсис; ранній неонатальний сепсис; чинники ризику; хоріонамніоніт; антибіотикопрофілактика у пологах; стрептококи групи В; бактеріологічне дослідження крові; загальний аналіз крові; С-реактивний білок; антибактеріальна терапія

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Посилання


.1 Poriadok transportuvannia novonarodzhenykh ditei vysokoho perynatalnoho ryzyku v Ukraini [Procedure for transportation of high-perinatal at-risk infants in Ukraine]. Nakaz MOZ Ukrainy vid 28.11.2013r. №1024 [Internet]. Kyiv: MOZ Ukrainy; 2013[tsytovano 2014 Tra 17]. Dostupno: https://zakon.rada.gov.ua/laws/show/z2110-13 (in Ukrainian).

.2 Pro zatverdzhennia Protokolu medychnoho dohliadu za zdorovoiu novonarodzhenoiu dytynoiu[Approval of the Protocol for the Care of a Healthy Newborn Baby]. Nakaz MOZ Ukrainy vid 04.04.2005r. № 152 [Internet]. Kyiv: MOZ Ukrainy; 2005[tsytovano 2014 Tra 25]. Dostupno: http://old.moz.gov.ua/ua/portal/dn_20050404_152.html (in Ukrainian).

.3 Pro zatverdzhennia Protokolu medychnoho dohliadu za novonarodzhenoiu dytynoiu z maloiu masoiu tila pry narodzhenni [Approval of the Protocol for the Care of a Newborn Baby with a Low Body Weight at Birth]. Nakaz MOZ Ukrainy vid 29.08.2006r. № 584 [Internet]. Kyiv: MOZ Ukrainy; 2006[tsytovano 2014 Cher 7]. Dostupno: http://old.moz.gov.ua/ua/portal/dn_20060829_584.html(in Ukrainian).

.4 Pro zatverdzhennia klinichnoho Protokolu nadannia medychnoi dopomohy dytyni z dykhalnymy rozladamy [Approval of the Clinical Protocol for the Provision of Medical Care for a Child with Respiratory Disorders]. Nakaz MOZ Ukrainy vid 21.08.2008r. № 484[Internet]. Kyiv: MOZ Ukrainy; 2008[tsytovano 2014 Cher 12]. Dostupno: http://old.moz.gov.ua/ua/portal/dn_20080821_484.html. (in Ukrainian).

.5 Berezhnoi VV, redaktor. Pediatriia. T.1. Kyiv; 2013. Shunko YeIe, Kostiuk OO, Krasnova YuIu. Hniino-septychni zakhvoriuvannia u novonarodzhenykh. Neonatalnyi sepsys[Purulent-septic diseases in newborns. Neonatal sepsis]. S.150-67. (in Ukrainian).

.6 Pro zatverdzhennia ta vprovadzhennia medyko-tekhnolohichnykh dokumentiv zi standartyzatsii medychnoi dopomohy z pochatkovoi, reanimatsiinoi i pisliareanimatsiinoi dopomohy novonarodzhenym v Ukraini[On approval and introduction of medical-technological documents on standardization of medical care for initial, resuscitation and post-resuscitation care of newborns in Ukraine]. Nakaz MOZ Ukrainy vid 28.03.2014r. № 225[Internet]. Kyiv: MOZ Ukrainy; 2014[tsytovano 2014 Cher 20]. Dostupno: https://zakon.rada.gov.ua/rada/show/v0225282-14 (in Ukrainian).

.7 Pickering LK, Baker CJ, Long SS, MCMillan JA, editor. Red Book: 2006 Report of the Committee on Infectious Diseases [Internet]. 27th ed. Elk Grove Village, IL, 2006 [cited 2014 May 23]. Group B Streptococcal Infectionsp. 620-7. Available from: https://redbook.solutions.aap.org/DocumentLibrary/2006%20RB.pdf

.8 ACOG Committee Opinion: number 279, December 2002. Prevention of early-onset group B streptococcal disease in newborns. Obstet Gynecol. 2002;100(6):1405-12. doi: 10.1016/s0029-7844(02)02629-7

.9 Antibiotics for early-onset neonatal infection: antibiotics for prevention and treatment for early-onset neonatal infection. NICE Clinical Guidelines. London[Internet]; 2012[cited 2014 Apr 6]. 325 p. Available from: https://www.nice.org.uk/guidance/cg149/evidence/cg149-antibiotics-for-earlyonset-neonatal-infection-full-guideline2

.10 Flenady V, King J. Antibiotics for prelabour rupture membrans at or near term (Review). Cochrane Database Syst Rev[Internet]. 2002[cited 2014 Mar 12];3:CD001807. Available from: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD001807/full

.11 Atherton N, Parsons SJ, Mansfield P. Attendance of paediatricians at elective Caesarean sections performed under regional anaesthesia: is it warranted? J Paediatr Child Health. 2006;42(6):332-6. doi: 10.1111/j.1440-1754.2006.00886.x

.12 Brierley J, Carcillo JA, Choong K, Cornell T, Decaen A, Deymann A, et al. Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine. Crit Care Med. 2009;37(2):666-88. doi: 10.1097/CCM.0b013e31819323c6.

.13 CDC. Adoption of perinatal group B streptococcal disease prevention recommendations by prenatal-care providers - Connecticut and Minnesota, 1998. MMWR Morb Mortal Wkly Rep. 2000;49(11):228-32.

.14 CDC. Adoption of hospital policies for prevention of perinatal group B streptococcal disease. – United States, 1997. MMWR Morb Mortal Wkly Rep. 1998;47(32):665-70.

.15 CDC. Early-onset group B streptococcal disease.−United States, 1998-1999. JAMA. 2000;284(12):1508-10.

.16 CDC. Hospital-based policies for prevention of perinatal group B streptococcal disease.−United States, 1999. MMWR Morb Mortal Wkly Rep. 2000;49(41):936-40.

.17 Polin RA, Watterberg K, Benitz W, Eichenwald E. The Conundrum of Early-Onset Sepsis. Pediatrics. 2014;133(6):1122-3. doi: 10.1542/peds.2014-0360.

.18 Cruz AT, Perry AM, Williams EA, Graf JM, Wuestner ER, Patel B. Implementation of Goal-Directed Therapy for Children With Suspected Sepsis in the Emergency Department. Pediatrics [Internet]. 2011[cited 2014 May 4];127(3):e758-66. Available from: https://pediatrics.aappublications.org/content/127/3/e758.long

.19 CDC. Early-onset and late-onset neonatal group B streptococcal disease − United States, 1996-2004. MMWR Morb Mortal Wkly Rep. 2005;54(47):1205-8.

.20 Remington JS, Klein JO, Wilson CB, Baker CJ. Infectious Diseases of the Fetus and Newborn Infant. 6th ed. Philadelphia: Elsevier Saunders, 2006. Edwards MS, Nizet V, Baker CJ. Chapter 13 - Group B Streptococcal Infections. P.403-64. doi: 10.1016/B0-72-160537-0/50015-3

.21 Escobar GJ, Li DK, Armstrong MA, Gardner MN, Folck BF, Verdi JE, et al. NHS Maternity Statistics 2000-1, DH. Neonatal sepsis workups in infants >/=2000 grams at birth: A population-based study. Pediatrics. 2000;106(2):256-63. doi: 10.1542/peds.106.2.256

.22 Polin RA, Denson S, Brady M. Epidemiology and Diagnosis of Health Care–Associated Infections in the NICU. Pediatrics. 2012;129(4):e1104-9. doi: 10.1542/peds.2012-0147.

.23 Ohlsson A, Shah VS. Intrapartum antibiotics for known maternal group B streptococcal colonization (Review). Cochrane Database Syst Rev [Internet]. 2009[cited 2014 May 4];3: CD007467. Available from: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD007467.pub2/full

.24 Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, et al. Late-Onset Sepsis in Very Low Birth Weight Neonates: The Experience of the NICHD Neonatal Research Network. Pediatrics. 2002;110(2):285-91. doi: 10.1542/peds.110.2.285

.25 Rastogi S, Rastogi D, Sundaram R, Kulpa J, Parekh AJ. Leukemoid reaction in extremely low-birth-weight infants. Am J Perinatol. 1999;16(2):93-7. doi: 10.1055/s-2007-993843

.26 Manroe BL, Weinberg AG, Rosenfeld CR, Browne R. The neonatal blood count in health and disease. I. Reference values for neutrophilic cells. J Pediatr. 1979;95(1):89-98. doi: 10.1016/s0022-3476(79)80096-7

.27 Manroe BL. Peer Review Status: Internally Peer Reviewed / [et al.].

.28 Managing Newborn Problems: A guide for doctors, nurses and midwives. World Health Organization. Geneva, 2003. 338p.

.29 Polin RA. Management of Neonates With Suspected or Proven Early-Onset Bacterial Sepsis. Рediatrics. 2012;129(5):1006-15. doi: 10.1542/peds.2012-0541.

.30 Edwards MS. Clinical features and diagnosis of sepsis in term and late preterm infants. Literature review. UpToDate[Internet]. 2014[cited 2014 May 16]. Available from: https://www.uptodate.com/contents/clinical-features-evaluation-and-diagnosis-of-sepsis-in-term-and-late-preterm-infants

.31 Mouzinho A, Rosenfeld CR, Sánchez PJ, Risser R. Revised reference ranges for circulating neutrophils in very-low-birth-weight infants. Pediatrics. 1994;94(1):76-82.

.32 NeoFax® Neonatology Drug and Enteral Nutrition Reference Book Discontinued in Print Format as of June 2012; Now Available Via the Web by Subscription [Internet]. 2012[cited 2014 May 3]. Available from: https://www.businesswire.com/news/home/20120620005240/en/NeoFax%C2%AE-Neonatology-Drug-Enteral-Nutrition-Reference-Book

.33 Brady MT, Polin RA. Prevention and Management of Infants With Suspected or Proven Neonatal Sepsis. Pediatrics. 2013;132(1):166-8. doi: 10.1542/peds.2013-1310.

.34 Prevention of Perinatal Group B Streptococcal Disease Revised Guidelines from CDC, 2010. MMWR Recomm Rep. 2010;59(RR-10):1-36.

.35 The Prevention of Early-Onset Neonatal Group B Streptococcal Disease. Green-top Guideline № 36. 2-nd ed.[Internet]. 2012[cited 2014 Apr 15]. Available from: http://www.tynwald.org.im/business/hansard/20002020/k130430%20WA4A.pdf

.36 Baker CJ, Byington CL, Polin RA. Policy statement – Recommendations for the Prevention of Perinatal Group B Streptococcal (GBS). Pediatrics. 2011;128(3):611-6. doi: 10.1542/peds.2011-1466.

.37 Vouloumanou EK, Plessa E, Karageorgopoulos DE, Mantadakis E, Falagas ME. Serum procalcitonin as a diagnostic marker for neonatal sepsis: a systematic review and meta-analysis. Intensive Care Med. 2011;37(5):747-62. doi: 10.1007/s00134-011-2174-8.

.38 Smaill F. Intrapartum antibiotics for Group B streptococcal colonisation. Cochrane Database Syst Rev[Internet]. 2000[cited 2014 Mar 14];(2):CD000115. Available from: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD000115/full

.39 Singhi S, Khilnani P, Lodha R, Santhanam I. Guidelines for treatment of septic shock in resource limited environments. Journal of Pediatrics Infection Diseases. 2009;4(2):173-92.




Copyright (c) 2019 E.A. Kostiyk, E.E. Shynko, Y.Y. Krasnova

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Журнал «Неонатологія, хірургія та перинатальна медицина» ISSN 2413-4260 (Online), ISSN 2226-1230 (Print) This work is licensed under a Creative Commons Attribution 4.0 International License.